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The Endocrine System


The endocrine system comprises various glands, including the pituitary, thyroid, adrenal, pancreas, and gonads. Each gland produces specific hormones that influence bodily functions. For instance, the thyroid gland regulates metabolism through hormones like thyroxine (T4) and triiodothyronine (T3), while the pancreas manages blood glucose levels through insulin and glucagon.

DIABETES MELLITUS

This chronic condition arises when the body fails to produce sufficient insulin (Type 1) or becomes resistant to insulin's effects (Type 2). Managed through lifestyle modifications, oral medications, or insulin therapy, diabetes is a leading cause of morbidity, contributing to complications such as cardiovascular disease, neuropathy, and nephropathy.

Hypothyroidism (Underactive thyroid)

A condition characterised by insufficient thyroid hormone production, hypothyroidism can lead to symptoms such as fatigue, weight gain, and depression. Effective management often includes levothyroxine supplementation, restoring hormonal balance and improving quality of life.

Hyperthyroidism (Overactive Thyroid)

Hyperthyroidism results from excessive production of thyroid hormones, often due to Graves' disease. Symptoms may include weight loss, increased heart rate, and anxiety. Treatment options include antithyroid medications, radioiodine therapy, or surgery, tailored to the patient's needs.


FAQ

1Does having diabetes increase your risk of thyroid disease?
Having diabetes increases your risk of thyroid disease. Usually, one autoimmune illness leads to another. Should you have diabetes, you will have to manage your blood sugar levels so that they do not rise. Having diabetes or low insulin can result in fluctuating blood sugar levels that worsen due to thyroid disease.
2What are the most common endocrine conditions to look out for?
Apart from diabetes type 1, which is a severe disorder that needs to be monitored, other widespread endocrine conditions include:
• Addison’s disease occurs when the adrenal glands at the top of the kidneys secrete insufficient hormones,cortisol and aldosterone.
• Cushing’s syndrome arises from the pituitary gland secreting the steroid hormone, adrenocorticotropic in excess. As a result, you will develop a “moon face," a round face, and you will feel tired or grow weak.
• Graves’ disease is due to an overstimulated immune system that causes the thyroid gland to produce a surplus of hormones. As a result, graves' disease symptoms include anxiety, tremor and sensitivity to heat, fatigue and palpitations.
• Hashimoto’s thyroiditis is an autoimmune condition whereby the own body’s cells attack the thyroid gland. Symptoms of weight gain and lethargy accompany this condition.
3Can a thyroidectomy be performed minimally invasively?
A minimally invasivethyroidectomy is similar to traditional open thyroidectomy surgery. However, it involves making a smaller incision, less than 6cm over the front of the neck. In the interim, surgeons can adopt the lateral retraction or the Sofferman technique, which involves cutting across the strap muscles.
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Dr Victor Montori, on shared decision-making